Multiple Sclerosis (MS) is a neurodegenerative disease that is associated with brain tissue damage primarily observed as white matter abnormalities such as lesions. We present a novel, fully automatic segmentation method for MS lesions in brain MRI that [...]

Diffusion tensor imaging (DTI) allows a quantitative study of the underlying geometry and architecture of white matter. We have developed a suite of open source tools for quantitative analysis of DTI suitable for use in clinical research studies. We have [...]

Many statistical shape analysis methods produce various types of data about the analyzed surfaces, such as p-value maps, distance maps, 3D difference vectors and local covariance matrices. This data is often too large and thus difficult to be properly [...]

Active contour segmentation and its robust implementation using level sets have been studied thoroughly in the medical image analysis literature. Despite the availability of these powerful methods, clinical research still largely relies on manual [...]

Shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes between healthy and pathological structures. This manuscript presents a comprehensive set of tools for the [...]