Insight Journal

The Insight Journal is an Open Access on-line publication covering the domain of medical image processing and visualization.

The unique characteristics of the Insight Journal include:

- Open-access to articles, data, code, and reviews
- Open peer-review that invites discussion between reviewers and authors
- Emphasis on reproducible science via automated code compilation and testing
- Support for continuous revision of articles, code, and reviews

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Pseudo-CT generation from multiple MR images for small animal irradiation

Gutierrez Diaz S., Van Holen R., Descamps B., Vanhove C.

Introduction. Computed tomography (CT) is the standard imaging modality for radiation therapy treatment planning (RTTP) because of its ability to provide information on electron density. However, magnetic resonance (MR) imaging provides superior soft tissue [...]

downloaded 969 times, viewed 9932 times and no review.

A novel atlas-selection approach for multi-atlas based segmentation using the correlation of inter-atlas similarities

Raudaschl P., Fritscher K., Zaffino P., Sharp G., Spadea M., Schubert R.

Automated segmentation is a frequently applied task in the course of medical imaging. Furthermore, it is a substantial component of image-guided radiotherapy. Atlas based segmentation is one of the most frequently used approach for automated segmentation. [...]

downloaded 1435 times, viewed 10123 times and no review.

Multimodal Analysis of Vasogenic Edema in Glioblastoma Patients for Radiotherapy Planning

Lê M., Delingette H., Kalpathy-Cramer J., Gerstner E., Shih H., Batchelor T., Unkelbach J., Ayache N.

Glioblastoma (GBM) is the most common type of primary brain tumor, which is characterized by an infiltrative growth pattern. In current practice, radiotherapy planning is primarily based upon T2 FLAIR MRI despite its known lack of specificity in the detection [...]

downloaded 759 times, viewed 7767 times and no review.

Validation of real-time intensity based 2D/3D registration for image guided radiotherapy

Furtado H., Underwood T., Depuydt T., Stock M., Georg D., Birkfellner W.

Patient motion during radiotherapy or intra-fractional motion, is one of the major sources of uncertainty in dose application. 2D/3D registration is an intensity based method used successfully to track tumor motion with the potential to reduce uncertainty. [...]

downloaded 1048 times, viewed 9521 times and no review.

Deformable Registration with Discontinuity Preservation using Multi-Scale MRF

Seo D., Van Baar J.

Deformable (2D or 3D) medical image registration is a challenging problem. Existing approaches assume that the underlying deformation is smooth. This smoothness assumption allows for solving the deformable registration at a coarse resolution and interpolate [...]

downloaded 970 times, viewed 7291 times and no review.

Deformable Registration with Discontinuity Preservation using Multi-Scale MRF

Seo D., Van Baar J.

downloaded 1062 times, viewed 7930 times and no review.

Improvements in SlicerRT, the radiation therapy research toolkit for 3D Slicer

Pinter C., Lasso A., Wang A., Sharp G.C., Jaffray D., Fichtinger G.

Purpose: Recent years have seen growing interest in adaptive radiation therapy (RT), but the existing software tools are not ideal for research use, as they are either expensive and closed proprietary applications or free open-source packages with limited [...]

downloaded 1168 times, viewed 9420 times and no review.

Gauss-Newton Method for Segmentation assisted Deformable Registration

Jurisic M., Fechter T., Hauler F., Furtado H., Nestle U., Birkfellner W.

In this work, we try to develop a fast converging method for segmentation assisted deformable registration. The segmentation step consists of a piece-wise constant Mumford-Shah energy model while reg- istration is driven by the sum of squared distances of [...]

downloaded 546 times, viewed 49716 times and no review.

Visualization of 4D-PET/CT, Target Volumes and Dose Distribution: Applications in Radiotherapy Planning

Schlachter M., Fechter T., Nestle U., Bühler K.

In radiation treatment (RT) planning medical doctors need to consider a variety of information sources for anatomical and functional target volume delineation. The validation and inspection of the defined target volumes and the resulting RT plan is a complex [...]

downloaded 895 times, viewed 6980 times and no review.

Automatic accuracy measurement for multi-modal rigid registration using feature descriptors

Hauler F., Jurisic M., Furtado H., Sabatini U., Laprie A., Nestle U., Birkfellner W.

In radiotherapy (RT) for tumor delineation and diagnostics, complementary information of multi-modal images is used. Using high ionizing radiation, the accuracy of registered volume data is crucial; therefore a reliable and robust evaluation method for [...]

downloaded 1027 times, viewed 8472 times and no review.

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