Authors provide code to generate medial curve (centerlines) of binary volumes.  finary shapes by providing a medialness map based on the computation of the Average Outward Flux (AOF) followed by an iterative-ordered thinning algorithm. 

Work is based on works of Bouix et al and Sidiqqi et al. Those works describe the generation of medial axis using the AOF and ordered thinning.

Tests are included in thr source code, as well as data to run the method in several vascular structures

Source code and data are included with thee paper. The method is well explained and the original articles are referenced.

Code compiled smoothly with ITK 3.XX.

I would suggest to smooth distance maps with a gaussian kernel before using them with the method.

Code is useable and can be integrated easily with other ITK filters easily.

Code is commented and has the standard templated filter structure of ITK. I compiled it succesfully in Microsoft and GCC compilers.

Data includes sunthetic and real vascular volumes.

A good amount of work in medical imaging relies on vascular analysis, so this method will be highly useful.

Also, medial curves can be used in several shape comparation techniques.

In the context of medical imaging I believe centerline calculation is a relevant task. ITK will greatly benefit of having a bunch of methods for centerline calculation.