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Impact of motion correction on the quantitative analysis of DCE-MR Images

Mosaliganti, Kishore, Jia, Guang, Heverhagen, Johannes, Machiraju, Raghu, Saltz, Joel, Knopp, Michael
Harvard Medical School
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Please use this identifier to cite or link to this publication: http://hdl.handle.net/1926/47
New: Prefer using the following doi: https://doi.org/10.54294/n2m2ru
Published in The Insight Journal - 2005 MICCAI Open-Source Workshop.
Submitted by Kishore Mosaliganti on 2005-08-05T22:28:22Z.

Dynamic magnetic resonance imaging (DCE-MRI) carried out with contrast media such as Gd-chelate complex (Gd-DTPA) allows the non-invasive assessment of microcirculatory characteristics of malignant lesions. Quantitative estimation of lesion parameters from the passage of the contrast media requires the use of pharmacokinetic two-compartment model. The input to the model is the time-intensity plot from a region of interest (ROI) covering the lesion extent. The lengthy imaging process, elasticity of the organs and patient movement result in complex deformations in the subject requiring 3D motion correction for ROI alignment. This paper presents results on applying the Thirion Demon's 3D elastic matching procedure in the ITK framework on the two-compartment lesion parameters. Registration, meanwhile involves interpolation and smoothing operations thereby affecting the time-intensity plots. We explore the trade-offs that arise between registration and lesion parameter estimation. Experiments on synthesized and real deformation are presented.